Quatre amis immatures qui tiennent un pub irlandais à Philadelphie essaient de s'intégrer dans le monde adulte du travail et des relations sociales. Mais leurs biais et leurs préjugés leur font rencontrer de nombreux problèmes qui produisent tout autant de situations inconfortables.
After discovering that he might have cancer, Mac and Dennis attempt to find a woman who will sleep with Charlie. In the midst of their search, Mac falls in love with a transsexual he meets at the bar named Carmen. Overwhelmed by the extra workload that she had to take on since Charlie has taken a leave of absence, Dee tries to get Dennis to hire a recently out of work actress friend to help out.
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