Quatre amis immatures qui tiennent un pub irlandais à Philadelphie essaient de s'intégrer dans le monde adulte du travail et des relations sociales. Mais leurs biais et leurs préjugés leur font rencontrer de nombreux problèmes qui produisent tout autant de situations inconfortables.
When Psycho Pete, long lost member of the freight train, is released from the mental hospital, Dennis and Dee rush to get him recommitted while Charlie and Mac attempt to restore him to his former hard-partying form.
Charlie goes into overdrive when he's notified that the health inspector will be arriving that day. Meanwhile, the rest of the gang is trying to exploit a flaw in the air-miles reward system.