Quatre amis immatures qui tiennent un pub irlandais à Philadelphie essaient de s'intégrer dans le monde adulte du travail et des relations sociales. Mais leurs biais et leurs préjugés leur font rencontrer de nombreux problèmes qui produisent tout autant de situations inconfortables.
After Frank shoots Dennis and Dee, they resolve to take Frank’s gun away. Mac and Charlie go on a road trip with their moms to get their inheritances -- for Mac, it’s letters written by his grandfather which have fallen into his Uncle Donald’s hands, while for Charlie, it’s a jar of teeth that is now in the hands of his sisters, Bunny and Candy.