Quatre amis immatures qui tiennent un pub irlandais à Philadelphie essaient de s'intégrer dans le monde adulte du travail et des relations sociales. Mais leurs biais et leurs préjugés leur font rencontrer de nombreux problèmes qui produisent tout autant de situations inconfortables.
Charlie and Dee have been stealing Frank's delicious meats, so Frank leaves out human meat to get back at them. Driven by their cannibalistic needs, Charlie and Dee go in search of human flesh. Mac and Dennis harass Frank for hunting defenseless animals and think it would be much more badass to hunt something that could fight back ... like a human.
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